![]() ![]() ![]() ITT is better regarded as a complete trial strategy for design, conduct and analysis rather than as an approach to analysis alone. One potential solution to this problem is a statistical concept called ITT analysis. Hence, RCTs often suffer from two major complications, i.e., noncompliance and missing outcomes. Moreover, in some studies, drop out of the subjects is a problem. But unfortunately, one practical problem that investigators usually come across in RCT is that subjects do not always follow instructions. In an ideal scenario, every subject enrolled in RCT would follow instructions and complete their allocated treatment as described in the protocol and thus contribute data which were complete in all respects. The purpose of the RCT is to ensure that the groups differ only with respect to the interventions being compared. Randomization in clinical trials reduces bias. In an RCT, the study subjects is randomly allocated to receive one of the treatments under study after assessment of eligibility but before the intervention is administered. RCTs are the ideal design in assessing the efficacy and safety of medicine. ![]()
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